Defining the Coordination of Immune Responses to Pathogens

Grant number: 1136550 | Funding period: 2018 - 2022

Completed

Abstract

Understanding how immune responses are coordinated is critical for the design of new therapies and vaccines to target infectious diseases and cancers. This project will utilise advanced imaging combined with novel tools to dissect the complex interactions that occur between immune cells as they are activated and patrol the body to eliminate infectious pathogens.

Related publications (7)

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An optimized protocol for the isolation of rare stromal cell populations from the mouse spleen

YO Alexandre, SN Mueller

2022-12-16

Lymphoid tissue stromal cells are important regulators of spleen homeostasis and immune responses. Here, we present an optimized p..

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Corneal tissue-resident memory T cells form a unique immune compartment at the ocular surface

JK Loi, YO Alexandre, K Senthil, D Schienstock, S Sandford, S Devi, SN Christo, LK Mackay, HR Chinnery, PB Osborne, LE Downie, EK Sloan, SN Mueller

2022-05-24

The eye is considered immune privileged such that immune responses are dampened to protect vision. As the most anterior compartmen..

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Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior*

D Schienstock, SN Mueller

2022-03-01

The analysis of cellular behavior using intravital multi-photon microscopy has contributed substantially to our understanding of t..

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A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity

YO Alexandre, D Schienstock, HJ Lee, LC Gandolfo, CG Williams, S Devi, B Pal, JR Groom, W Cao, SN Christo, CL Gordon, G Starkey, R D’Costa, LK Mackay, A Haque, B Ludewig, GT Belz, SN Mueller

2022-01-14

The spleen is a compartmentalized organ that serves as a blood filter and safeguard of systemic immune surveillance. Labyrinthine ..

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CD8 and CD4 T cells infiltrate into the brain during plasmodium berghei ANKA infection and form long-term resident memory

N Ghazanfari, JL Gregory, S Devi, D Fernandez-Ruiz, L Beattie, SN Mueller, WR Heath

2021-09-15

In the Plasmodium berghei ANKA mouse model of malaria, accumulation of CD8<sup>+</sup> T cells and infected RBCs in the brain prom..

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Intravital microscopy of dynamic single-cell behavior in mouse mammary tissue

CA Dawson, SN Mueller, GJ Lindeman, AC Rios, JE Visvader

2021-04-01

Multiphoton intravital imaging is essential for understanding cellular behavior and function in vivo. The adipose-rich environment..

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Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling

CA Dawson, B Pal, F Vaillant, LC Gandolfo, Z Liu, C Bleriot, F Ginhoux, GK Smyth, GJ Lindeman, SN Mueller, AC Rios, JE Visvader

2020-05-01

Macrophages are diverse immune cells that reside in all tissues. Although macrophages have been implicated in mammary-gland functi..

University of Melbourne Researchers